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Author: Uwe R. Müller Publisher: Springer Science & Business Media ISBN: 3540265783 Category : Medical Languages : en Pages : 380
Book Description
Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.
Author: Uwe R. Müller Publisher: Springer Science & Business Media ISBN: 3540265783 Category : Medical Languages : en Pages : 380
Book Description
Ithasbeenstatedthatourknowledgedoublesevery20years,butthatmaybe an understatement when considering the Life Sciences. A series of discoveries and inventions have propelled our knowledge from the recognition that DNA isthegeneticmaterialtoabasicmolecularunderstandingofourselvesandthe living world around us in less than 50 years. Crucial to this rapid progress was thediscoveryofthedouble-helicalstructureofDNA,whichlaidthefoundation forallhybridizationbasedtechnologies. Thediscoveriesofrestrictionenzymes, ligases, polymerases, combined with key innovations in DNA synthesis and sequencing ushered in the era of biotechnologyas a new science with profound sociological and economic implications that are likely to have a dominating in?uence on the development of our society during this century. Given the process by which science builds on prior knowledge, it is perhaps unfair to single out a few inventions and credit them with having contributed most to thisavalancheofknowledge. Yet,therearesurelysomethatwillberecognized as having had a more profound impact than others, not just in the furthering of our scienti?c knowledge, but by leveraging commercial applications that provide a tangible return to our society. The now famous Polymerase Chain Reaction, or PCR, is surely one of those, as it has uniquely catalyzed molecular biology during the past 20 years, and continues to have a signi?cant impact on all areas that involve nucleic acids, ranging from molecular pathology to forensics. Ten years ago micro- ray technology emerged as a new and powerful tool to study nucleic acid - quences in a highly multiplexed manner, and has since found equally exciting and useful applications in the study of proteins, metabolites, toxins, viruses, whole cells and even tissues.
Author: Francesco Falciani Publisher: Garland Science ISBN: 0203967275 Category : Science Languages : en Pages : 276
Book Description
Microarray Technology Through Applications provides the reader with an understanding, from an applications perspective, of the diverse range of concepts required to master the experimental and data analysis aspects of microarray technology. The first chapter is a concise introduction to the technology and provides the theoretical background required to understand the subsequent sections. The following chapters are a series of case studies representative of the most general and important applications of microarray technology, including CGH, analysis of gene expression, SNP arrays and protein arrays. The case studies are written by experts in the field and describe prototypic projects, indicating how to generalize the approach to similar studies. There are detailed step-by-step protocols describing the specific experimental and data analysis protocols mentioned in the case study section. There is also information on printing glass DNA microarray slides and data interpretation. Colour figures and data sets are provided on the website at http://www.garlandscience.com/9780415378536
Author: Sergey Yurish Publisher: Lulu.com ISBN: 846164154X Category : Technology & Engineering Languages : en Pages : 560
Book Description
Sensors and Biosensors, MEMS Technologies and its Applications (Book Series: Advances in Sensors: Reviews, Vol. 2) - 18 chapters with sensor related state-of-the-art reviews and descriptions of the latest achievements written by experts from academia and industry from 12 countries: China, India, Iran, Malaysia, Poland, Singapore, Spain, Taiwan, Thailand, UK, Ukraine and USA. This volume is divided into three main parts: physical sensors, biosensors, nanoparticles, MEMS technologies and applications. With this unique combination of information in each volume, the Advances in Sensors: Reviews Book Series will be of value for scientists and engineers in industry and at universities, to sensors developers, distributors, and users. Like the 1st volume of this Book Series, the 2nd volume also has been organized by topics of high interest.
Author: Osvaldo Gervasi Publisher: Springer ISBN: 3540320458 Category : Computers Languages : en Pages : 1342
Book Description
The four volume set assembled following The 2005 International Conference on Computational Science and its Applications, ICCSA 2005, held in Suntec International Convention and Exhibition Centre, Singapore, from 9 May 2005 till 12 May 2005, represents the ?ne collection of 540 refereed papers selected from nearly 2,700 submissions. Computational Science has ?rmly established itself as a vital part of many scienti?c investigations, a?ecting researchers and practitioners in areas ranging from applications such as aerospace and automotive, to emerging technologies such as bioinformatics and nanotechnologies, to core disciplines such as ma- ematics, physics, and chemistry. Due to the shear size of many challenges in computational science, the use of supercomputing, parallel processing, and - phisticated algorithms is inevitable and becomes a part of fundamental t- oretical research as well as endeavors in emerging ?elds. Together, these far reaching scienti?c areas contribute to shape this Conference in the realms of state-of-the-art computational science research and applications, encompassing the facilitating theoretical foundations and the innovative applications of such results in other areas.
Author: Steen Knudsen Publisher: John Wiley & Sons ISBN: 047167026X Category : Science Languages : en Pages : 184
Book Description
Written for biologists and medical researchers who don't have anyspecial training in data analysis and statistics, Guide to Analysisof DNA Microarray Data, Second Edition begins where DNA arrayequipment leaves off: the image produced by the microarray. Thetext deals with the questions that arise starting at this point,providing an introduction to microarray technology, then moving onto image analysis, data analysis, cluster analysis, andbeyond. With all chapters rewritten, updated, and expanded to include thelatest generation of technology and methods, Guide to Analysis ofDNA Microarray Data, Second Edition offers practitioners reliableinformation using concrete examples and a clear, comprehensiblestyle. This Second Edition features entirely new chapters on: * Image analysis * Experiment design * Automated analysis, integrated analysis, and systemsbiology * Interpretation of results Intended for readers seeking practical applications, this textcovers a broad spectrum of proven approaches in this rapidlygrowing technology. Additional features include further readingsuggestions for each chapter, as well as a thorough review ofavailable analysis software.
Author: Wan-Li Xing Publisher: Springer Science & Business Media ISBN: 3662050927 Category : Science Languages : en Pages : 134
Book Description
This book brings together contributions from internationally renowned experts in the biochip field. The authors present not only their latest research work, but also discuss current trends in biochip technology. Specific topics range from microarray technology and its applications to lab-on-a-chip technology.
Author: Suresh Kumar Gahlawat Publisher: Springer ISBN: 9811047022 Category : Medical Languages : en Pages : 401
Book Description
This book explores the recent advancements in cutting-edge techniques and applications of Biotechnology. It provides an overview of prospects and applications while emphasizing modern, and emerging areas of Biotechnology. The chapters are dedicated to various field of Biotechnology including, genome editing, probiotics, in-silico drug designing, nanoparticles and its applications, molecular diagnostics, tissue engineering, cryopreservation, and antioxidants. It is useful for both academicians and researchers in the various disciplines of life sciences, agricultural sciences, medicine, and Biotechnology in Universities, Research Institutions, and Biotech companies. This book provides the readers with a comprehensive knowledge of topics in Genomics, Bionanotechnology, Drug Designing, Diagnostics, Therapeutics, Food and Environmental Biotechnology. The chapters have been written with special reference to the latest developments in the frontier areas of Biotechnology that impacts the Biotech industries.
Author: Robert S. Matson Publisher: CRC Press ISBN: 1439855633 Category : Medical Languages : en Pages : 325
Book Description
Microarrays play an increasingly significant role in drug discovery. The commercial landscape has changed dramatically over the past few years and researchers have made great advancements with regard to construction and use. Now in its second edition, Applying Genomic and Proteomic Microarray Technology in Drug Discovery highlights, describes, and evaluates current scientific research using microarray technology in genomic and proteomic applications. Updated and revised to reflect recent progress in the field, the second edition discusses: Expanded omics-driven applications, including the areas of metabolomics and chemical biology The commercialization of the microarray platform, with a historical perspective aimed at recognizing key technological developments Solid-supports (substrates) and surface chemistries currently used in the creation of nucleic acid and protein microarrays Different approaches to producing microarrays that achieve spot equality with the same number of molecules properly oriented The development of the gene expression microarray and representative applications The development of protein microarray technology, including its history and key applications Unique to this edition is a new chapter on multiplex assays that examines the development and applications of arrays across diverse platforms. It discusses applications for qPCR, multiplex lateral flow, and multiplex bead assays. It also presents platform-to-platform comparisons. Microarrays remain an invaluable tool for omics-based research not only in drug discovery, but in the life sciences, in clinical research, and for diagnostic applications worldwide. This volume presents the current state of the art on the utility of this technology to solve a host of important biological problems.
Author: Jürgen Popp Publisher: John Wiley & Sons ISBN: 3527410481 Category : Science Languages : en Pages : 1187
Book Description
This new handbook covers the world of biophotonics not only geographically -- with the editors coming from different continents -- but also in terms of content, since the authors come from the whole spectrum of biophotonic basic and applied research. Designed to set the standard for the scientific community, these three volumes break new ground by providing readers with the physics basics as well as the biological and medical background, together with detailed reports on recent technical advances. The Handbook also adopts an application-related approach, starting with the application and then citing the various tools to solve the scientific task, making it of particular value to medical doctors. Divided into several sections, the first part offers introductory chapters on the different fields of research, with subsequent parts focusing on the applications and techniques in various fields of industry and research. The result is a handy source for scientists seeking the basics in a condensed form, and equally a reference for quickly gathering the knowledge from neighboring disciplines. Absolutely invaluable for biophotonic scientists in their daily work.
Author: Sarah Afaq Publisher: Springer Nature ISBN: 9811661987 Category : Science Languages : en Pages : 134
Book Description
This book discusses advancements in the applications of nanoparticles in tissue engineering. It examines the applications of nanobiomaterials in hard tissue regeneration, fabrication, and characterization. The book also analyzes the implication of three-dimensional and four-dimensional fabrication techniques for the production of the scaffold in tissue engineering and their advantages over conventional scaffold production techniques. Further, it presents smart materials used in making 4-D scaffolds that imitate the dynamic response of tissue against natural stimuli and adapt to the microenvironment by changing their conformation or other properties. It also summarizes the growing field of biomolecular detection and biosensors in tissue engineering and the increasing prominence of nanoparticles in the biosensors. Further, it provides the future outlook and associated challenges of the application of nanomaterials in tissue engineering.
Author: Uwe R. Müller
Author: Uwe R. Müller
Author: Francesco Falciani
Author: Sergey Yurish
Author: Osvaldo Gervasi
Author: Steen Knudsen
Author: Wan-Li Xing
Author: Suresh Kumar Gahlawat
Author: Robert S. Matson
Author: Jürgen Popp
Author: Sarah Afaq