Differentiation, Tissue Adaptation and Function of Memory T Cells PDF Download
Are you looking for read ebook online? Search for your book and save it on your Kindle device, PC, phones or tablets. Download Differentiation, Tissue Adaptation and Function of Memory T Cells PDF full book. Access full book title Differentiation, Tissue Adaptation and Function of Memory T Cells by Weiguo Cui. Download full books in PDF and EPUB format.
Author: Weiguo Cui Publisher: Frontiers Media SA ISBN: 2889637956 Category : Languages : en Pages : 171
Book Description
Upon antigen encounter, naïve T cells differentiate into (i) effectors that combat infected or malignant cells, and at later time points, into (ii) memory cells that provide long-lasting immunity. This differentiation process allows some T cells to leave the confines of secondary lymphoid organs and to enter peripheral tissues in search of pathogens or tumor cells. These different environments pose specific challenges for effector and memory T cells to maintain homeostasis. T cells directed into the lungs are likely to encounter higher levels of oxygen, but lower amounts of nutrients than those directed into the intestinal epithelium. In addition to oxygen tension and nutrient concentrations, other key factors, such as the commensal flora and stromal components, create unique conditions that require tissue-specific adaptations of T cells. These steady state conditions can dramatically change during infection when inflammatory mediators and T cell growth factors are released, requiring the immediate response of T cells. The gradual changes imposed by growing tumors can also be challenging for T cells due to competition with rapidly cycling tumor cells that deplete essential resources of oxygen and glucose. The strategies that T cells employ to respond to the diverse cues from their surroundings are the focus of current research. It appears that next to circulating memory T cells that are confined to the circulation and those that survey all of the peripheral tissues, dedicated populations of resident memory T cells exist that can optimally adapt to the local circumstances within each tissue. Restrictions on the metabolic requirements of T cells residing in tumor tissue have been found to directly impact on effector functions such as cytokine production. The fundamental principles of how the machinery of T cells can translate local cues into tissue-specific differentiation processes are fascinating and warrant further investigation.
Author: Weiguo Cui Publisher: Frontiers Media SA ISBN: 2889637956 Category : Languages : en Pages : 171
Book Description
Upon antigen encounter, naïve T cells differentiate into (i) effectors that combat infected or malignant cells, and at later time points, into (ii) memory cells that provide long-lasting immunity. This differentiation process allows some T cells to leave the confines of secondary lymphoid organs and to enter peripheral tissues in search of pathogens or tumor cells. These different environments pose specific challenges for effector and memory T cells to maintain homeostasis. T cells directed into the lungs are likely to encounter higher levels of oxygen, but lower amounts of nutrients than those directed into the intestinal epithelium. In addition to oxygen tension and nutrient concentrations, other key factors, such as the commensal flora and stromal components, create unique conditions that require tissue-specific adaptations of T cells. These steady state conditions can dramatically change during infection when inflammatory mediators and T cell growth factors are released, requiring the immediate response of T cells. The gradual changes imposed by growing tumors can also be challenging for T cells due to competition with rapidly cycling tumor cells that deplete essential resources of oxygen and glucose. The strategies that T cells employ to respond to the diverse cues from their surroundings are the focus of current research. It appears that next to circulating memory T cells that are confined to the circulation and those that survey all of the peripheral tissues, dedicated populations of resident memory T cells exist that can optimally adapt to the local circumstances within each tissue. Restrictions on the metabolic requirements of T cells residing in tumor tissue have been found to directly impact on effector functions such as cytokine production. The fundamental principles of how the machinery of T cells can translate local cues into tissue-specific differentiation processes are fascinating and warrant further investigation.
Author: Tolga Soyata Publisher: CRC Press ISBN: 1498750761 Category : Mathematics Languages : en Pages : 440
Book Description
GPU Parallel Program Development using CUDA teaches GPU programming by showing the differences among different families of GPUs. This approach prepares the reader for the next generation and future generations of GPUs. The book emphasizes concepts that will remain relevant for a long time, rather than concepts that are platform-specific. At the same time, the book also provides platform-dependent explanations that are as valuable as generalized GPU concepts. The book consists of three separate parts; it starts by explaining parallelism using CPU multi-threading in Part I. A few simple programs are used to demonstrate the concept of dividing a large task into multiple parallel sub-tasks and mapping them to CPU threads. Multiple ways of parallelizing the same task are analyzed and their pros/cons are studied in terms of both core and memory operation. Part II of the book introduces GPU massive parallelism. The same programs are parallelized on multiple Nvidia GPU platforms and the same performance analysis is repeated. Because the core and memory structures of CPUs and GPUs are different, the results differ in interesting ways. The end goal is to make programmers aware of all the good ideas, as well as the bad ideas, so readers can apply the good ideas and avoid the bad ideas in their own programs. Part III of the book provides pointer for readers who want to expand their horizons. It provides a brief introduction to popular CUDA libraries (such as cuBLAS, cuFFT, NPP, and Thrust),the OpenCL programming language, an overview of GPU programming using other programming languages and API libraries (such as Python, OpenCV, OpenGL, and Apple’s Swift and Metal,) and the deep learning library cuDNN.
Author: C.D. Woody Publisher: Springer Science & Business Media ISBN: 1461256429 Category : Psychology Languages : en Pages : 484
Book Description
The basis of learning appears to be a network of interconnected adaptive elements (such as those found in the brain) by means of which transforms between inputs and outputs are performed. By adaptive I mean that the element can change in some systematic manner and in so doing alter the transform between input and output. In living systems, transmission within the neural network involves cpded nerve impulses and other physical chemical processes that form reflections of sensory stimuli and incipient motor behavior. The properties of the transmission network become significant determinants of behavior and depend on the mechanisms of neuronal adaptation, the means by which the connectivities between different neurons are modified. Particular paths through the network become labeled with reference to specific inputs and outputs. The network then operates through labeled interconnections linking specific elements within the network and through the mechanisms that underlie each element's adaptation. The adap tive features are crucial to learning and imply some associated, underlying mnemonic process. The labeling is of consequence with regard to the resulting specificities of stimulus reception and motor performance that characterize adaptive behavior. Memory involves time-dependent information processing relying on en coding and retrieval as well as storage itself. In the brain, engrams can be defined as those elemental adaptive changes that take place when learning and memory storage occur. Persistent engrammatic modifications of neuronal structure commonly arise through the same associative mechanisms responsi ble for learned behavior [397, 486, 759, 1020].
Author: Wm. Fahnestock Publisher: BoD – Books on Demand ISBN: 3382177293 Category : Fiction Languages : en Pages : 298
Book Description
Reprint of the original, first published in 1871. The publishing house Anatiposi publishes historical books as reprints. Due to their age, these books may have missing pages or inferior quality. Our aim is to preserve these books and make them available to the public so that they do not get lost.
Author: Peter E. Langford Publisher: Psychology Press ISBN: 1135426465 Category : FAMILY & RELATIONSHIPS Languages : en Pages : 312
Book Description
Vygotsky's Developmental and Educational Psychology aims to demonstrate how we can come to a new and original understanding of Vygotsky's theories through knowledge of their cultural, philosophical and historical context.
Author: Vibha M. Jha Publisher: Springer Nature ISBN: 9811571759 Category : Medical Languages : en Pages : 118
Book Description
This book discusses the evolution of sleep and its possible function in the higher invertebrates and vertebrates, including humans. It describes the current concept of sleep and its functions, based on research on the mammalian system. To date, electrophysiological recordings of the brain waves, muscle activity, and eye movements are the only tools available for characterizing the sleep architecture in the majority of animals. In mammals and birds, only two distinct types of sleep are found – non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Since the discovery of REM sleep, studies have been performed to understand the purpose of the two distinct sleep states in higher vertebrates (birds and mammals), and how REM sleep was evolved. The book summarizes the role of both REM and NREM sleep in the proper functioning of the brain and body. It covers various aspects of the role of sleep in important physiological processes, including memory consolidation, induction of synaptic plasticity, energy restoration, enhancing immune response, and maturation of neuronal circuitries during early life. Lastly, the book reviews the effects of chronic/acute sleep deprivation on memory consolidation, obesity, and the immune system in animal models and humans.
Author: Weiguo Cui
Author: Weiguo Cui
Author: Tolga Soyata
Author: C.D. Woody
Author: Thackery I. Brown
Author: Wm. Fahnestock
Author: C. D. Woody
Author: 
Author: George Frederick Shrady
Author: Peter E. Langford
Author: Vibha M. Jha